In 1991, David G. Bailey, PhD, and colleagues found that grapefruit juice increased blood concentrations of the blood pressure drug Plendil to possibly dangerous levels. Grapefruit juice, they later learned, slows down a key liver enzyme that clears Plendil -- and about 40 other drugs -- from the body.
Now Bailey reports that grapefruit, orange, and apple juices decrease the absorption of several important medications:
* The allergy drug Allegra, available generically as fexofenadine
* The antibiotics ciprofloxacin (Cipro, Proquin), levofloxacin (Levaquin), and itraconazole (Sporanox)
* The beta-blocker blood pressure drugs atenolol (Tenormin), celiprolol, and talinolol
* The transplant-rejection drug cyclosporine (Gengraf, Neoral)
* The cancer chemotherapy etoposide (Toposar, Vepesid)
"This is just the tip of the iceberg. I'm sure we'll find more and more drugs that are affected this way," Bailey says in a news release.
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